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Article

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.

Molecular biology of the cell - 1 Apr 2003

Williams Byron C, Li ZeXiao, Liu Songtao, Williams Erika V, Leung Garmay, Yen Tim J, Goldberg Michael L

Abstract excerpt

The Zeste-White 10 (ZW10) and Rough Deal (ROD) proteins are part of a complex necessary for accurate chromosome segregation. This complex recruits cytoplasmic dynein to the kinetochore and participates in the spindle checkpoint. We used immunoaffinity chromatography and mass spectroscopy to identify the Drosophila proteins in this complex. We found that the complex contains an additional protein we name Zwilch....

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Identifiers

PMID: 12686595
DOI: 10.1091/mbc.e02-09-0624
PMCID: PMC153108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.PMID 12686595Read ↗

The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.Semantic proximity Read ↗

Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.Semantic proximity Read ↗

Determinants of Drosophila zw10 protein localization and function.Semantic proximity Read ↗

A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Semantic proximity Read ↗

ZW10 helps recruit dynactin and dynein to the kinetochore.Semantic proximity Read ↗

The RZZ complex facilitates Mad1 binding to Bub1 ensuring efficient checkpoint signalingSemantic proximity Read ↗

The RZZ complex integrates spindle checkpoint maintenance with dynamic expansion of unattached kinetochoresSemantic proximity Read ↗

Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila.Semantic proximity Read ↗

Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila.Semantic proximity Read ↗

A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.Semantic proximity Read ↗

Conservation of the centromere/kinetochore protein ZW10.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

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