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Article

Discovery and validation of information theory-based transcription factor and cofactor binding site motifs.

Nucleic acids research - 17 Mar 2017

Lu Ruipeng, Mucaki Eliseos J, Rogan Peter K

Abstract excerpt

Data from ChIP-seq experiments can derive the genome-wide binding specificities of transcription factors (TFs) and other regulatory proteins. We analyzed 765 ENCODE ChIP-seq peak datasets of 207 human TFs with a novel motif discovery pipeline based on recursive, thresholded entropy minimization. This approach, while obviating the need to compensate for skewed nucleotide composition, distinguishes true binding...

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Identifiers

PMID: 27899659
DOI: 10.1093/nar/gkw1036
PMCID: PMC5389469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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