Article

Fused in sarcoma regulates DNA replication timing and progression

2020-04-24

Abstract excerpt

Fused in sarcoma (FUS ) encodes a low complexity RNA-binding protein with diverse roles in transcriptional activation and RNA processing. While oncogenic fusions of FUS and transcription factor DNA-binding domains are associated with soft tissue sarcomas, dominant mutations in FUS cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). FUS has also been implicated in DNA double-strand break re...

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Literature Corpus work: 422095c2-f06d-52be-9d0e-0d583b5ad20e
DOI: 10.1101/2020.04.22.055343

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