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Article

Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.

The Journal of biological chemistry - 1 Aug 2022

Johnson Michelle A, Nuckols Thomas A, Merino Paola, Bagchi Pritha, Nandy Srijita, Root Jessica, Taylor Georgia, Seyfried Nicholas T, Kukar Thomas

Abstract excerpt

Accumulation of cytoplasmic inclusions containing fused in sarcoma (FUS), an RNA/DNA-binding protein, is a common hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis neuropathology. We have previously shown that DNA damage can trigger the cytoplasmic accumulation of N-terminally phosphorylated FUS. However, the functional consequences of N-terminal FUS phosphorylation are unknown. To...

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Identifiers

PMID: 35709984
DOI: 10.1016/j.jbc.2022.102135
PMCID: PMC9372748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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