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Article

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jun 2014

Deng Qiudong, Holler Christopher J, Taylor Georgia, Hudson Kathryn F, Watkins William, Gearing Marla, Ito Daisuke, Murray Melissa E, Dickson Dennis W, Seyfried Nicholas T, Kukar Thomas

Abstract excerpt

Abnormal cytoplasmic accumulation of Fused in Sarcoma (FUS) in neurons defines subtypes of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). FUS is a member of the FET protein family that includes Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 2N (TAF15). FET proteins are predominantly localized to the nucleus, where they bind RNA and DNA to modulate...

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Source

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Identifiers

PMID: 24899704
DOI: 10.1523/JNEUROSCI.0172-14.2014
PMCID: PMC4044245

Genes

FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.PMID 24899704Read ↗

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ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.Semantic proximity Read ↗

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.Semantic proximity Read ↗

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.Semantic proximity Read ↗

Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.Semantic proximity Read ↗

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.Semantic proximity Read ↗

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALSSemantic proximity Read ↗

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