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Article

Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS

25 Aug 2025

Abstract excerpt

Mutations in the Fused in Sarcoma (FUS) gene cause familial amyotrophic lateral sclerosis (ALS), characterized by selective degeneration of spinal motor neurons (sMNs) with relative sparing of cortical neurons (CNs). The mechanisms underlying this cell-type vulnerability remain unclear. Here, we compare CNs and sMNs derived from FUS-ALS models to assess differential responses to FUS mutations. We find that CNs...

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PMID: 40857153
DOI: 10.1016/j.celrep.2025.116113

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