Article

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration

2023-07-12

Abstract excerpt

<title>Abstract</title> <p>This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS). Endogenous FUS interacts with and recruits mtDNA Ligase IIIα (mtLig3) to DNA damage sites within mitochondria, a relationship essential for...

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Literature Corpus work: bd0d852e-4b4b-5b60-a12f-3279cd1b331f
DOI: 10.21203/rs.3.rs-3152718/v1

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