Article
Cell-Type-Dependent Recruitment Dynamics of FUS Protein at Laser-Induced DNA Damage Sites.
International journal of molecular sciences - 20 Mar 2024
Niu Yu, Pal Arun, Szewczyk Barbara, Japtok Julia, Naumann Marcel, Glaß Hannes, Hermann Andreas
Abstract excerpt
Increased signs of DNA damage have been associated to aging and neurodegenerative diseases. DNA damage repair mechanisms are tightly regulated and involve different pathways depending on cell types and proliferative vs. postmitotic states. Amongst them, fused in sarcoma (FUS) was reported to be involved in different pathways of single- and double-strand break repair, including an early recruitment to DNA damage....
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