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Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

24 Sept 2020

Abstract excerpt

The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. In addition to its roles in RNA metabolism, FUS is implicated in the maintenance of DNA integrity. In this review, we examine the participation of FUS in major DNA...

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Neurogenetic and Muscular Disorders Research
Prion Diseases and Protein Misfolding
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32987654
DOI: 10.3390/ijms21197020

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