Article

High levels of DNA replication initiation factors indicate ATRi sensitivity via excessive origin firing

2025-02-28

Abstract excerpt

Inhibitors of ATR, a central kinase controlling DNA replication origin firing and cellular checkpoint activity, are currently in multiple clinical trials, yet mechanisms underpinning sensitivity and robust patient stratification biomarkers are lacking. We used functional genomics approaches to identify molecular mechanisms driving sensitivity to the ATR inhibitor (ATRi) ceralasertib. Replication stress-associated...

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Literature Corpus work: b2c15b9a-d818-53f2-99c9-a4bbb26f214a
DOI: 10.1101/2025.02.27.640046

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