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Article

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.

Physiological reviews - 1 Jul 2018

Jentsch Thomas J, Pusch Michael

Abstract excerpt

CLC anion transporters are found in all phyla and form a gene family of eight members in mammals. Two CLC proteins, each of which completely contains an ion translocation parthway, assemble to homo- or heteromeric dimers that sometimes require accessory β-subunits for function. CLC proteins come in two flavors: anion channels and anion/proton exchangers. Structures of these two CLC protein classes are...

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PMID: 29845874
DOI: 10.1152/physrev.00047.2017

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CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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