Article
A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl-/H+ transport cycle.
eLife - 20 Apr 2020
Chavan Tanmay S, Cheng Ricky C, Jiang Tao, Mathews Irimpan I, Stein Richard A, Koehl Antoine, Mchaourab Hassane S, Tajkhorshid Emad, Maduke Merritt
Abstract excerpt
Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl- for H+). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps and inconsistencies in our understanding have remained. One limitation has been that global conformational change -...
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