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Article

Molecular insights into the human CLC-7/Ostm1 transporter.

Science advances - 1 Aug 2020

Zhang Sensen, Liu Yang, Zhang Bing, Zhou Jun, Li Tianyu, Liu Zhiqiang, Li Yang, Yang Maojun

Abstract excerpt

CLC family proteins translocate chloride ions across cell membranes to maintain the membrane potential, regulate the transepithelial Cl- transport, and control the intravesicular pH among different organelles. CLC-7/Ostm1 is an electrogenic Cl-/H+ antiporter that mainly resides in lysosomes and osteoclast ruffled membranes. Mutations in human CLC-7/Ostm1 lead to lysosomal storage disorders and severe...

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Identifiers

PMID: 32851177
DOI: 10.1126/sciadv.abb4747
PMCID: PMC7423370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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