Article

Distinct causes of three phenotypic hallmarks of hematopoietic aging

2025-01-19

Abstract excerpt

Hematopoietic aging is characterized by chronic inflammation associated with myeloid bias, HSC accumulation, and functional HSC impairment. Yet it remains unclear how inflammation promotes these aging phenotypes. NFkappaB both responds to and directs inflammation, and we present an experimental model of elevated NFkappaB activity (IkappaBminus) to dissect its role in hematopoietic aging phenotypes. We found that w...

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Literature Corpus work: 41e5ad81-e535-5337-9b07-d5512c68c44a
DOI: 10.1101/2025.01.14.632900

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