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Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?

25 Dec 2024

Abstract excerpt

Aging exerts a profound impact on the hematopoietic system, leading to increased susceptibility to infections, autoimmune diseases, chronic inflammation, anemia, thrombotic events, and hematologic malignancies. Within the field of experimental hematology, the functional decline of hematopoietic stem cells (HSCs) is often regarded as a primary driver of age-related hematologic conditions. However, aging is clearly...

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PMID: 39725143
DOI: 10.1016/j.exphem.2024.104698

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