Article

AP-1 complex activation is a conserved signature of immune system aging and a potential regulator of inflammaging in human and mice

2021-11-17

Abstract excerpt

<title>Abstract</title> <p>Increased inflammation with age (i.e., inflammaging) is a hallmark of aging conserved in human and mice, but the underlying mechanisms are poorly understood, partially because a systematic comparative study of mouse and human immune system aging is lacking. We uncovered epigenomic/transcriptomic signatures of aging in spleen and peripheral blood lymphocytes from young (3 months) and old...

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Literature Corpus work: 1e59047e-c80b-5e13-a40e-7c1346d13f64
DOI: 10.21203/rs.3.rs-1051151/v1

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