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Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases

10 Jan 2025

Abstract excerpt

ABSTRACT: Aging and chronic inflammation are associated with overabundant myeloid-primed multipotent progenitors (MPPs) among hematopoietic stem and progenitor cells (HSPCs). Although hematopoietic stem cell (HSC) differentiation bias has been considered a primary cause of myeloid bias, whether it is sufficient has not been quantitatively evaluated. Here, we analyzed bone marrow data from the IκB-...

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PMID: 39791596
DOI: 10.1182/blood.2024025598

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