Article

Interstrand Crosslinks in Donor DNA Boost Gene Editing in Human Cells

2022-03-12

Abstract excerpt

Co-introduction of targeted nucleases and DNA/RNA templates encoding new genomic sequence is the basis for rapid, effective, and iterable gene editing workflows for therapeutic, agricultural, and basic science applications. Extensive optimization of reagent delivery and nuclease activity have improved genome editing workflows, but comparatively few efforts have been made to alter the gene editing activity of templ...

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Literature Corpus work: 41d59a9b-2678-5162-b219-2f286376a3c3
DOI: 10.1101/2022.03.11.484022

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