Article

Modeling the effect of spatial structure on solid tumor evolution and ctDNA composition

2023-11-11

Abstract excerpt

Circulating tumor DNA (ctDNA) monitoring, while sufficiently advanced to reflect tumor evolution in real time and inform on cancer diagnosis, treatment, and prognosis, mainly relies on DNA that originates from cell death via apoptosis or necrosis. In solid tumors, chemotherapy and immune infiltration can induce spatially variable rates of cell death, with the potential to bias and distort the clonal composition of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41c3abe3-f56d-5325-ae13-8e2c051dcb1a
DOI: 10.1101/2023.11.10.566658

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling the effect of spatial structure on solid tumor evolution and ctDNA compositionDOI 10.1101/2023.11.10.566658Read

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic dataSemantic proximity Read

State-dependent evolutionary models reveal modes of solid tumor growthSemantic proximity Read

High-density sampling reveals volume growth in human tumoursSemantic proximity Read

Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage TracingSemantic proximity Read

Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.Semantic proximity Read

LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterationsSemantic proximity Read

Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in GlioblastomaSemantic proximity Read

Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastomaSemantic proximity Read

LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterationsSemantic proximity Read

Spatial population structure can reverse the dependence of mutant burden on the death-to-birth ratio of cellsSemantic proximity Read

Evolutionary dynamics and molecular features of intra-tumor heterogeneitySemantic proximity Read

Spatial structure governs the mode of tumour evolutionSemantic proximity Read