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LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations

21 Jul 2021

Abstract excerpt

Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from longitudinally collected cfDNA samples sequenced through cost-effective low-pass whole-genome sequencing. LiquidCNA utilizes somatic copy number alteration (SCNA) to simultaneously genotype and...

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PMID: 34401670
DOI: 10.1016/j.isci.2021.102889

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