Article

LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations

2021-01-06

Abstract excerpt

Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally-invasive monitoring of tumour evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from longitudinally collected cfDNA samples based on somatic copy number alterations (SCNAs). LiquidCNA utilises SCNA profiles derived through cost-effective low-pass whole genome sequencing to automatica...

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Literature Corpus work: 7650f5ac-d5ec-52bc-9137-3da100ecf5ee
DOI: 10.1101/2021.01.05.425414

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