Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.

Genome medicine - 20 May 2021

Weber Zachary T, Collier Katharine A, Tallman David, Forman Juliet, Shukla Sachet, Asad Sarah, Rhoades Justin, Freeman Samuel, Parsons Heather A, Williams Nicole O, Barroso-Sousa Romualdo, Stover Elizabeth H, Mahdi Haider, Cibulskis Carrie, Lennon Niall J, Ha Gavin, Adalsteinsson Viktor A, Tolaney Sara M, Stover Daniel G

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) offers minimally invasive means to repeatedly interrogate tumor genomes, providing opportunities to monitor clonal dynamics induced by metastasis and therapeutic selective pressures. In metastatic cancers, ctDNA profiling allows for simultaneous analysis of both local and distant sites of recurrence. Despite the promise of ctDNA sampling, its utility in real-time genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circulating Tumor DNA
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to DNA Copy Number Variations

Share to Exome Sequencing

Share to High-Throughput Nucleotide Sequencing

Share to Liquid Biopsy

Share to Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 34016182
DOI: 10.1186/s13073-021-00895-x
PMCID: PMC8136103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.PMID 34016182Read ↗

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.Semantic proximity Read ↗

Noninvasive MRD monitoring and profiling of clonal evolution by ctDNA in patients with advanced cancers treated within molecular tumor boardsSemantic proximity Read ↗

The dynamic range of circulating tumor DNA in metastatic breast cancer.Semantic proximity Read ↗

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.Semantic proximity Read ↗

Capturing tumor heterogeneity and clonal evolution in solid cancers using circulating tumor DNA analysis.Semantic proximity Read ↗

The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer.Semantic proximity Read ↗

Circulating tumor DNA reveals complex biological features with clinical relevance in metastatic breast cancerSemantic proximity Read ↗

Integrating ctDNA Dynamics and Sequential Organoid Drug Screening Enhances Breast Cancer Treatment Efficacy.Semantic proximity Read ↗

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clustersSemantic proximity Read ↗

Circulating tumour DNA testing in metastatic breast cancer: Integration with tissue testing.Semantic proximity Read ↗

Dissecting Tumor Heterogeneity by Liquid Biopsy—A Comparative Analysis of Post-Mortem Tissue and Pre-Mortem Liquid Biopsies in Solid NeoplasiasSemantic proximity Read ↗

Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.