Article

Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage Tracing

2026-02-06

Abstract excerpt

Spatial transcriptomics reveals tissue organization but lacks in vivo lineage-tracing methods applicable to humans. We introduce SpaceTracer, a computational framework that accurately detects somatic single-nucleotide variants (SNVs) directly from spatial transcriptomics data. By leveraging naturally occurring somatic SNVs, SpaceTracer reconstructs cellular phylogenies within native tissue architecture, enabling t...

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Identifiers and source

Literature Corpus work: c3eb6945-8d53-5ca7-b7c5-b01e4af7d3e9
DOI: 10.64898/2026.02.04.703493

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