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A frameshift mutation in the methyltransferase rlmN is associated with increased linezolid resistance in Mycobacterium tuberculosis

2025-11-20

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Linezolid is a key component of treatment regimens for multidrug-resistant and extensively drug-resistant tuberculosis, which is caused by the pathogen Mycobacterium tuberculosis (MTB). Resistance to linezolid in MTB has traditionally been attributed to mutations in the 23S rRNA ( rrl ) and ribosomal protein L3 ( rplC ), but only a fraction of clinically observed linezolid resistance is explained by mutations i...

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Literature Corpus work: 41ad6803-844a-526f-be34-84ad8e37fd50
DOI: 10.1101/2025.11.20.689544

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A frameshift mutation in the methyltransferase rlmN is associated with increased linezolid resistance in Mycobacterium tuberculosisDOI 10.1101/2025.11.20.689544Read

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A frameshift mutation in the methyltransferase <i>rlmN</i> is associated with increased linezolid resistance in <i>Mycobacterium tuberculosis</i>

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