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Article

Acquired linezolid resistance in DR-TB: genotype-phenotype discordance and molecular heterogeneity in a retrospective cohort.

BMC infectious diseases - 14 Feb 2026

Zhou Wenqiang, Wang Qingfeng, Nie Wenjuan, Shi Wenhui, Yang Yang, Qi Wenjie, Lu Yu, Chu Naihui

Abstract excerpt

BACKGROUND: Linezolid is an important drug for the treatment of drug-resistant tuberculosis (DR-TB). Acquired linezolid resistance threatens treatment efficacy. This study aimed to analyze the risk factors and molecular mechanisms of linezolid-acquired resistance in a clinical cohort. METHODS: We conducted a retrospective study of 61 patients with DR-TB who failed linezolid-containing regimens (2017–2021). Paired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41691168
DOI: 10.1186/s12879-026-12869-8
PMCID: PMC12980970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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