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Article

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.

mBio - 9 May 2017

Belousoff Matthew J, Eyal Zohar, Radjainia Mazdak, Ahmed Tofayel, Bamert Rebecca S, Matzov Donna, Bashan Anat, Zimmerman Ella, Mishra Satabdi, Cameron David, Elmlund Hans, Peleg Anton Y, Bhushan Shashi, Lithgow Trevor, Yonath Ada

Abstract excerpt

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus This high-resolution structural information demonstrated that a single amino acid deletion in ribosomal protein uL3 confers linezolid resistance despite being located 24 Å away from the linezolid binding pocket in the...

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Share to Cryoelectron Microscopy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

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Identifiers

PMID: 28487427
DOI: 10.1128/mBio.00395-17
PMCID: PMC5424203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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