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Article

Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.

The Journal of antibiotics - 1 Jan 2025

Yang Wenjing, Chen Taoran, Zhou Qi, Xu Jiancheng

Abstract excerpt

Linezolid binds to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis by preventing the formation of the initiation complex. Oxazolidinone antimicrobial drugs represent the last line of defense in treating Staphylococcus aureus infections; thus, resistance to linezolid in S. aureus warrants high priority. This article examines the major mechanisms of resistance to linezolid in S....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39420155
DOI: 10.1038/s41429-024-00778-4
PMCID: PMC11700844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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