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Article

Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome

6 Dec 2011

Abstract excerpt

Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance mechanisms involve small alterations to the linezolid binding site, so this review will therefore focus on the various changes that can adversely affect drug...

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Identifiers

PMID: 22143525
DOI: 10.1128/aac.05702-11

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Resistance to Linezolid Caused by Modifications at Its Binding Site on the RibosomePMID 22143525Read ↗

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.Semantic proximity Read ↗

Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.Semantic proximity Read ↗

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningSemantic proximity Read ↗

Resistance to linezolid in Staphylococcus spp. clinical isolates associated with ribosomal binding site modifications: novel mutation in domain V of 23S rRNA.Semantic proximity Read ↗

Linezolid: a review of its properties, function, and use in critical care.Semantic proximity Read ↗

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.Semantic proximity Read ↗

Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics.Semantic proximity Read ↗

Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.Semantic proximity Read ↗

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.Semantic proximity Read ↗

Mutations within the rplD Gene of Linezolid-Nonsusceptible Streptococcus pneumoniae Strains Isolated in the United States.Semantic proximity Read ↗

A frameshift mutation in the methyltransferase <i>rlmN</i> is associated with increased linezolid resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.Semantic proximity Read ↗

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