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Article

Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid.

Antimicrobial agents and chemotherapy - 1 Apr 2016

Zhang Shuo, Chen Jiazhen, Cui Peng, Shi Wanliang, Shi Xiaohong, Niu Hongxia, Chan Denise, Yew Wing Wai, Zhang Wenhong, Zhang Ying

Abstract excerpt

Linezolid (LZD) has become increasingly important for the treatment of multidrug-resistant tuberculosis (MDR-TB), but its mechanisms of resistance are not well characterized. We isolated 32 mutants ofMycobacterium tuberculosiswith reduced susceptibility to LZD, which was accounted for byrrlandrplCmutations in almost equal proportions, causing lower and higher MICs, respectively. Our findings provide useful...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26810645
DOI: 10.1128/AAC.02941-15
PMCID: PMC4808145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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