Article
The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.
Molecular neurodegeneration - 4 Jun 2025
Karunakaran Devi Krishna Priya, Ley Makenna, Guo Joanna, Khatri Ammaarah, Sadleir Katherine, Popovic Jelena, Upadhyay Arun Kumar, Savas Jeffrey, Procissi Daniele, Atwal Jasvinder, Vassar Robert
Abstract excerpt
Alzheimer's disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and synaptic and neuronal loss. Recently, a rare autosomal dominant coding mutation, T835M, in the Un-coordinated 5c (UNC5C) netrin receptor gene was segregated with late-onset AD (LOAD). Overexpression of T835M in primary hippocampal neurons increased cell death in response to neurotoxic stimuli including beta-amyloid (Aβ)...
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