Article

Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions

2022-10-30

Abstract excerpt

<h4>Summary</h4> Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that Androgen Receptor (AR), a steroid hormone-regulated transcription factor, forms condensates through multivalent interactions in response to androgen signaling to orchestrate enhancer assembl...

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Literature Corpus work: 4163bec5-4a80-5611-ba79-935b8a2456ec
DOI: 10.1101/2022.10.28.514297

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