A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.

doi:10.1126/sciadv.ade2175

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Article

A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance.

Science advances - 17 Mar 2023

Alegre-Martí Andrea, Jiménez-Panizo Alba, Martínez-Tébar Adrián, Poulard Coralie, Peralta-Moreno M Núria, Abella Montserrat, Antón Rosa, Chiñas Marcos, Eckhard Ulrich, Piulats Josep M, Rojas Ana M, Fernández-Recio Juan, Rubio-Martínez Jaime, Le Romancer Muriel, Aytes Álvaro, Fuentes-Prior Pablo, Estébanez-Perpiñá Eva

Abstract excerpt

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein interaction network, and binding to chromatin, resulting in altered transcription signatures and drug responses. Current structural information fails to explain the effect of pathological mutations on AR structure-function relationship. Here, we have...

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Identifiers

PMID: 36921044
DOI: 10.1126/sciadv.ade2175
PMCID: PMC10017050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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