Article

Allosteric interactions prime androgen receptor dimerization and activation

2022-02-21

Abstract excerpt

<h4>Summary</h4> The androgen receptor (AR) is a steroid receptor and master transcription factor that governs gene expression programs required for luminal development of prostate epithelium, formation of muscle tissue and maintenance of the male phenotype. AR misregulation is a hallmark of multiple malignancies, including prostate cancer, where AR hyperactivation and expansion of its transcriptome occur in part...

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Literature Corpus work: 798bb55c-f946-506a-a3ce-06f34de37708
DOI: 10.1101/2022.02.20.481229

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