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Article

Allosteric interactions prime androgen receptor dimerization and activation

20 Apr 2022

Abstract excerpt

The androgen receptor (AR) is a nuclear receptor that governs gene expression programs required for prostate development and male phenotype maintenance. Advanced prostate cancers display AR hyperactivation and transcriptome expansion, in part, through AR amplification and interaction with oncoprotein cofactors. Despite its biological importance, how AR domains and cofactors cooperate to bind DNA has remained...

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PMID: 35447082
DOI: 10.1016/j.molcel.2022.03.035

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