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Article

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers

13 Mar 2019

Abstract excerpt

The androgen receptor (AR) is commonly known as a key transcription factor in prostate cancer development, progression and therapy resistance. Genome-wide chromatin association studies revealed that transcriptional regulation by AR mainly depends on binding to distal regulatory enhancer elements that control gene expression through chromatin looping to gene promoters. Changes in the chromatin epigenetic landscape...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 30865928
DOI: 10.1530/erc-19-0032

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