Article

Rational optimization of a transcription factor activation domain inhibitor

2022-08-19

Abstract excerpt

<h4>Summary</h4> Transcription factors are among the most attractive therapeutic targets but are considered largely undruggable due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation domain of the androgen receptor, a therapeutic target for castration resistant prostate cancer, is key for its activity as a transcription factor by allowing...

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Literature Corpus work: 4c30293d-1cbf-50b2-a58f-458b97a351ef
DOI: 10.1101/2022.08.18.504385

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