Article

Cardiomyopathic mutations of lamin A perturb mutual interactions of lamin, nuclear membrane, and chromatin leading to LLPS

2024-10-08

Abstract excerpt

Lamins are nuclear intermediate filaments constituting the nuclear lamina which maintains the structural integrity of the nucleus and play a key role in the spatial organisation of the genome. Mutations in the lamin protein have been associated with diverse diseases collectively known as laminopathies. In this study, we focused on two lamin A mutants - E161K and K97E - associated with dilated cardiomyopathy (DCM)....

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Literature Corpus work: ece7e1e1-6896-56cb-9711-6cd5d9187661
DOI: 10.1101/2024.10.07.616979

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