Article

Spatially-resolved Photoproximity Profiling of MYC Identifies a MYC-BAF Liability in Cancer Cells

2025-10-19

Abstract excerpt

The c-MYC transcription factor is aberrantly expressed in most human cancers to enhance expression of proliferative gene programs. Owing to its pseudo-ordered structure and reliance on extensive and dynamic protein-protein interactions in distinct transcriptional regulatory complexes, defining context-specific MYC interactors has remained challenging. Therefore, mapping MYC-centered complex topologies in disease r...

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Identifiers and source

Literature Corpus work: 4df60740-75f5-5a21-b7fe-1492c8417401
DOI: 10.1101/2025.10.17.683176

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