Article
Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathies.
Nucleus (Austin, Tex.) - 1 Jan 2000
Camozzi Daria, Capanni Cristina, Cenni Vittoria, Mattioli Elisabetta, Columbaro Marta, Squarzoni Stefano, Lattanzi Giovanna
Abstract excerpt
Interconnected functional strategies govern chromatin dynamics in eukaryotic cells. In this context, A and B type lamins, the nuclear intermediate filaments, act on diverse platforms involved in tissue homeostasis. On the nuclear side, lamins elicit large scale or fine chromatin conformational changes, affect DNA damage response factors and transcription factor shuttling. On the cytoplasmic side,...
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