Article

Histone Variant H2A.J Links Epigenetic Reprogramming to Mitochondrial-dependent Kidney Regeneration under Radiation Stress

2026-06-19

Abstract excerpt

The histone variant H2A.J is implicated in radiation-induced senescence by promoting the transcription of inflammatory genes. While H2A.J expression increases in renal tubular epithelial cells (TECs) following ionizing radiation (IR), its functional role remains poorly understood. To investigate this, constitutive H2A.J knock-out (KO) mice and wild-type (WT) controls were subjected to CT-guided IR (fractionated wh...

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Literature Corpus work: 41176b3d-ee3f-56ee-aa47-71c7b3e2fa3e
DOI: 10.64898/2026.06.18.733158

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