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Article

Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.

International journal of molecular sciences - 30 Nov 2020

Isermann Anna, Mann Carl, Rübe Claudia E

Abstract excerpt

Irreparable double-strand breaks (DSBs) in response to ionizing radiation (IR) trigger prolonged DNA damage response (DDR) and induce premature senescence. Profound chromatin reorganization with formation of senescence-associated heterochromatin foci (SAHF) is an essential epigenetic mechanism for controlling the senescence-associated secretory phenotype (SASP). To decipher molecular mechanisms provoking...

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Share to Cellular Senescence
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Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Radiation, Ionizing

Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 33266246
DOI: 10.3390/ijms21239130
PMCID: PMC7729917

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