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Article

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury

24 Jul 2020

Abstract excerpt

In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in reparative responses to injury are not well understood. We have studied the mechanisms of transcriptional reprogramming in disease using murine kidney podocytes as a model for tissue injury. Podocytes are a crucial component of glomeruli, the filtration units of each nephron. Podocyte injury is the initial...

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PMID: 32754639
DOI: 10.1126/sciadv.abb5460

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