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Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair

2 Mar 2022

Abstract excerpt

Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a basal state after tubular injury. When injury is overwhelming or repetitive, however, that capacity is exceeded and incomplete repair results in fibrotic tissue replacing normal kidney parenchyma. Loss of nephrons correlates with reduced kidney function, which defines chronic kidney disease (CKD) and confers...

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PMID: 35235339
DOI: 10.1126/scitranslmed.abj4772

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