Article

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury

2020-02-19

Abstract excerpt

<h4>ABSTRACT</h4> In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in response to injury are not well understood. This is particularly true in kidney podocytes, injury to which is the common and initial event in many processes that lead End Stage Kidney Disease. WT1 is a master regulator of gene expression in podocytes, binding nearly all genes known to be cr...

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Literature Corpus work: 5165b4b7-00fb-5680-8d2d-5d411c0ce3ce
DOI: 10.1101/2020.02.18.954347

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