Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.

doi:10.1038/ncomms14995

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Article

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.

Nature communications - 10 May 2017

Contrepois Kévin, Coudereau Clément, Benayoun Bérénice A, Schuler Nadine, Roux Pierre-François, Bischof Oliver, Courbeyrette Régis, Carvalho Cyril, Thuret Jean-Yves, Ma Zhihai, Derbois Céline, Nevers Marie-Claire, Volland Hervé, Redon Christophe E, Bonner William M, Deleuze Jean-François, Wiel Clotilde, Bernard David, Snyder Michael P, Rübe Claudia E, Olaso Robert, Fenaille François, Mann Carl

Abstract excerpt

The senescence of mammalian cells is characterized by a proliferative arrest in response to stress and the expression of an inflammatory phenotype. Here we show that histone H2A.J, a poorly studied H2A variant found only in mammals, accumulates in human fibroblasts in senescence with persistent DNA damage. H2A.J also accumulates in mice with aging in a tissue-specific manner and in human skin. Knock-down of H2A.J...

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Identifiers

PMID: 28489069
DOI: 10.1038/ncomms14995
PMCID: PMC5436145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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