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A cross-species single-cell epigenome kidney atlas identifies epithelial cells as a driver of epigenetic aging

2026-01-23

Abstract excerpt

Epigenetic aging is a hallmark of chronic diseases, arising from sustained injuries and unresolved repairs. To investigate cell-type-specific epigenetic alterations, we built a cross-species single-cell multi-omics atlas of DNA methylomes, chromatin accessibilities, and transcriptomes on healthy, injured (human) and aging (mouse) kidneys. We identified accelerated epigenetic aging dominated by tubular epithelia in...

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Literature Corpus work
98d18a20-b0d4-52e6-9d4b-e4d4517354ce
DOI
10.64898/2026.01.22.700871
Open publication

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