Article

TCPGdb: A comprehensive T cell perturbation genomics database for identification of critical T cell regulators

2024-12-30

Abstract excerpt

CAR-T therapies utilizing T cells engineered with chimeric antigen receptors (CARs) have revolutionized the treatment of hematologic and immune-related malignancies. However, the anti-tumor capability of engineered CAR-T cells are often not persistent, which greatly dampen its clinical efficacy. To address this limitation, massive parallel genetic screens were widely used to identified novel targets and regulators...

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Literature Corpus work: 40fda1bc-e375-5a29-9f8b-7e3cb6cff19a
DOI: 10.1101/2024.12.30.630773

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