Article

speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

2021-08-23

Abstract excerpt

Chimeric antigen receptors (CARs) consist of an extracellular antigen-binding region fused to intracellular signaling domains, thus enabling customized T cell responses against target cells. Due to the low-throughput process of systematically designing and functionally testing CARs, only a small set of immune signaling domains have been thoroughly explored, despite their major role in T cell activation, effector f...

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Literature Corpus work: 721ded97-87ef-51f7-a44c-a732459038f0
DOI: 10.1101/2021.08.23.457342

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