Article

An <i>in vivo</i> CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> CAR-T cell therapies are revolutionizing the treatment of refractory and relapsed haematological malignancies, but many patients do not exhibit long-term responses, and these therapies are less effective against solid tumors. Poor persistence of CAR-T cells in patients is associated with therapeutic failure, highlighting the need to identify strategies promoting in vivo expansion. Here, we deve...

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Literature Corpus work: 55284aa9-ae92-5b81-b998-6ae4a019d01e
DOI: 10.1101/2025.03.28.645780

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