Article

Early Mitochondrial Defects in the 5xFAD mouse model of Alzheimer’s Disease

2022-08-01

Abstract excerpt

BACKGROUND Mitochondrial (MT) dysfunction is a hallmark of Alzheimer’s disease (AD). Amyloid Precursor Protein and Aβ peptides localize to MT and lead to MT dysfunction in familial forms of AD. This dysfunction may trigger subsequent types of pathology. Identification of the MT phenotypes that occur early is required to help understand the cascade of AD pathophysiology. METHODS The 5xFAD mouse model was used to...

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Literature Corpus work: 6a75f0c9-cbdc-5bb3-92b2-3ca0cff973fd
DOI: 10.21203/rs.3.rs-1898111/v1

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